Koulutukset ja tapahtumat
Tutkijoiden jatkokoulutus on olennainen osa 3R-osaamisen ylläpidossa. FIN3R järjestää 3R-alueen koulutustilaisuuksia ja kursseja. FIN3R osallistuu myös muiden tahojen sekä yliopistojen tohtorikoulujen kurssien järjestämiseen.
Yliopistot järjestävät säännöllisesti pätevöittämiskoulutusta koe-eläinten kanssa työskenteleville henkilöille. Valtakunnallisesti harmonisoiduilla kursseilla koulutetaan toimenpiteiden tekemiseen ja hankkeiden suunnitteluun. Kurssien tiedot löytyvät kunkin yliopiston tai yliopiston koe-eläinkeskuksen kotisivuilta.
- Fin3R WEBINARI, 15.1.2023 klo 14 (Helsinki, EET): Robust experimental design with the Experimental Design Assistant
There is growing concern in the community about the reliability of biomedical research results. Experimental design flaws, inappropriate analysis methods and incomplete reporting have all contributed to the publishing of inconsistent results. The NC3Rs has developed resources to assist researchers in designing more robust experiments, selecting the appropriate analysis method and reporting the experiment thoroughly. One such resource is the Experimental Design Assistant (EDA; https://eda.nc3rs.org.uk). The EDA is free online software with a supporting website to help researchers design more robust in vivo experiments.
This talk will cover key strategies to improve experimental design and highlight how the EDA can help researchers implement these. For example, the EDA can analyse your experimental design and suggest changes or highlight the implications of your specific experimental design choices, enabling you to make informed choices. Optimised experimental plans can then be communicated by exporting a PDF summarising key experimental design information from the EDA or sharing your experimental plan via a URL. This can make clearly communicating experimental plans with colleagues, funders and ethical review bodies easier, enhancing opportunities for collaboration, feedback and transparent reporting of your in vivo experiments.
Puhuja: Dr. Esther Pearl (NC3Rs, UK)
Esther Pearl is the Programme Manager for Experimental design at the UK’s National Centre for the Replacement, Refinement and Reduction of Animals in Research (the NC3Rs). Esther works to develop tools and resources to help researchers design experiments. This includes the Experimental Design Assistant (EDA), an online tool to guide researchers through the design of animal experiments, and the ARRIVE guidelines, which encourage improved design and reporting of animal research. Esther completed a PhD in Biochemistry at the University of Otago, New Zealand and worked with Xenopus as a postdoctoral researcher in the field of developmental biology at the Clinical Research Institute of Montreal, Canada, the National Xenopus Resource, USA and King’s College London, UK.
Jountaja: Vootele Voikar (University of Helsinki, FIN3R Refinement Director)
Tallenne löytyy täältä.
- FIN3R WEBINARI, 14.11.2023. KLO 14 (EET)
In recent years, there has been a strong drive to improve the inclusion of animals of both sex during in vivo research, driven by a need to improve sex representation in fundamental biology and drug development. This has resulted in inclusion mandates by a variety of funding bodies (e.g., NIH and MRC) and journals. This talk will dispel the common misconceptions that are no longer appropriate justification for studying only one sex. We then explore, how to build an appropriate justification to study only one sex at a case-by-case level. Finally, I will touch upon the impact of including both sexes on data analysis.
Puhuja: Dr. Natasha Karp (AstraZeneca, UK)
Natasha is a Director of Statistics within AstraZeneca leading a team of statisticians supporting preclinical research. In addition, Natasha is an active researcher publishing papers with a focus on the challenges within preclinical research with a particular interest in improving replicability, reproducibility, and generalizability of the studies. More recently, Natasha has published meta-research articles around the process of research. This has included qualitative research into blinding in in vivo studies, blockers to the engagement with sex inclusive research and the impact of sex inclusive research on statistical power.
Jountaja: Vootele Voikar (University of Helsinki, FIN3R Refinement Director)
Tallenne löytyy täältä.
- FIN3R WEBINARI, 11.10.2023. klo 14 (EEST)
Otsikko: The positive welfare impacts of playpens and ball pits in laboratory rats
Laboratory rodents display a rich behavioural repertoire such as rearing and climbing that is not possible in the current ‘shoebox’ style caging in which they are typically housed in animal facilities. Access to playpens or ball pits in small groups has been identified as a way in which rats can engage with a complex environment while also fulfilling social needs. In this talk I will discuss our recent work showing that just 5 minutes of access to a playpen objectively induces a positive affective state, and can reduce the potential negative welfare impact of common laboratory procedures.
Puhuja: Dr. Megan Jackson (University of Bristol UK)
Megan is a teaching associate at the University of Bristol. Her research involves the development of ethologically relevant behavioural tasks to assess rodent motivation, with a specific focus on apathy. She is the co-chair of the early career researcher 3Rs group, and she is a culture of care researcher representative.
Jountaja: Vootele Voikar
Tallenne löytyy täältä: https://www.helsinki.fi/fi/unitube/video/f96eda8c-86a5-4be6-8b69-d064fb0b94b9
- Fin3R webinaari, 22.8.2023. klo 14 (EEST)
Otsikko: “The benefits of systematic review and meta-analysis of animal research”
Puhuja: Dr. Kim Wever (Radboud University Medical Center, The Netherlands)
Jountaja: Vootele Voikar (University of Helsinki)
In this webinar, Dr. Kim Wever will outline how systematic review and meta-analysis can be valuable tools to inform and improve animal research. She will explain the basic principles of these methodologies, highlight their benefits and direct you to tools and resources in the field.
Tallenne löytyy täältä: https://www.helsinki.fi/fi/unitube/video/3d842024-cfac-4e71-a3e1-100a43c0e12a
About the speaker: Dr. Kimberley (Kim) Wever is a meta-research expert dedicated to maximizing the value of animal studies for human health and works at the Meta-Research team - Radboudumc (https://www.radboudumc.nl/en/research/departments/anesthesiology/meta-research-team). She is specialized in the use of systematic review and meta-analysis methodology to drive improvements in the design, validity and transparency of animal research, having more than 10 years’ experience in performing (methodological research on) evidence synthesis and validity assessments of animal studies, and in training scientists to do better research. The team has achieved many milestones in this area together with their long-standing colleagues at SYRCLE and CAMARADES (https://www.ed.ac.uk/clinical-brain-sciences/research/camarades).
- FIN3R ja Finnadvance webinari
Fin3R ja Finnadvance järjestävät 21.8.2023 yhdessä online-seminaarin aiheesta Eläinkokeita korvaavien metodien käytännöt tutkimuksessa ja yhteiskunnassa (engl. “3R workshop: Advances in alternative non-animal methods and policies” ).
Seminaari esittelee uusimpia eläinkokeita korvaavia metodeja sekä tämän hetkisiä käytäntöjä liittyen niiden käyttöön ja lisäämiseen tulevaisuudessa.
Tallenne löytyy täältä: Webinar: Advances in Alternative Non-Animal Methods and Policies :: FIN3R
Second FIN3R webinar - Animal distress during handling and procedures
9.5.2023, klo 14
Title: What the mouse face tells you - recognising distress during handling and procedures
Speakers: Elin Törnqvist (Karolinska Institutet and National Veterinary Institute in Sweden) and Julia Swan (University of Oulu), hosted by Vootele Voikar (University of Helsinki)
Tallenne löytyy täältä: https://www.helsinki.fi/fi/unitube/video/1a1d3b3d-f4ef-45f6-9794-f197c2d29854
The refinement aspect of 3Rs aims to alleviate or minimize potential pain, suffering, and distress, as well as enhance animal well-being. Understanding mouse behaviour and signs of distress is pertinent to evaluate efforts aiming at refinement.
In 2010, the mouse grimace scale was developed to assess pain in laboratory mice . This method allows for the identification of the degree of pain experienced by mice, shown in their facial expressions. Is it possible for signs of distress to also be found in their facial expressions?
We conducted a study to explore this question and will present our findings in this webinar. In addition, we will provide some practical tips on how to assess distress using facial expressions as well as how to train and handle your mice.
Reference Article: Swan J, Boyer S, Westlund K, Bengtsson C, Nordahl G, Törnqvist E. Decreased levels of discomfort in repeatedly handled mice during experimental procedures, assessed by facial expressions. Frontiers in Behavioral Neuroscience. 2023 Feb 2;17:15. DOI10.3389/fnbeh.2023.1109886
 Langford, D. J., Bailey, A. L., Chanda, M. L., Clarke, S. E., Drummond, T. E., Echols, S., et al. (2010). Coding of facial expressions of pain in the laboratory mouse. Nat. Methods 7, 447–449
- As a next step in connecting the animal welfare bodies in Finland, you are invited to Fin3R webinar – National Networks of Animal Welfare Bodies.
31.3.2023, klo 14
Stronger together – The role of the Portuguese Network of Animal Welfare Bodies in raising and harmonising standards across the country
Speaker: Nuno Franco (University of Porto), hosted by Vootele Voikar (University of Helsinki)
Tallenne löytyy täältä: https://www.helsinki.fi/fi/unitube/video/a97397a2-8a60-44b5-abcd-9596850e1d70
Abstract: While 2010/63/EU Directive demanded of scientific institutions to establish an Animal Welfare Body, there was no tradition in Portugal of having such bodies with such competences and attributions. This raised a challenge for newly-created AWB (ORBEAs, in Portugal) regarding how to define their mission, find their place, and establish authority in institutions, as well as in regard to liaising with the competent authority and national committee.
Faced with little to no guidance from the authorities, veterinarians, technicians, and laboratory animal scientists from across the country gathered in 2015 to discuss the most pressing matters in order to kick off AWB in their establishments, and the idea of working together as a network was born. The RedeORBEA was hence constituted, with a model of organization that is informal and decentralized, with no membership nor fees, and two co-opted coordinators. It holds regular surveys and censuses, disseminates information, and organizes courses and workshops, as well as annual symposia (with the 8th edition now being prepared), with support by SPCAL.
The most important contribution of RedeORBEA is providing a forum within which AWB members can ask questions and exchange experiences with peers facing the same problems, and be a unified voice when interacting with authorities.
Altogether, RedeORBEA has allowed raising and harmonising standards of competence and functionality in the planning, following, and evaluating procedures within institutions, benefitting both animals and the humans caring for them, thus promoting a culture of care.
Suomen 3R keskus Symposiumi
Suomen 3R keskus (FIN3R) järjestää vuosittaisen symposiumin Helsingin yliopiston Meilahden kampuksella 6-7.11.2023. Symposiumin tavoitteena on esitellä 3R-periaatteiden tämän hetkistä tilaa ja merkitystä biotieteellisessä ja farmakologisessa perustutkimuksessa sekä lääkekehityksessä. Luentojen lisäksi symposiumissa on mahdollisuus keskustella kuhunkin R:ään liittyvistä aiheista kotimaisten ja kansainvälisten asiantuntijoiden kanssa. Osana symposiumia keskiviikkona 7.11 järjestetään opiskelijoille suunnattu "Power analyysi työpaja”. Lopullinen ohjelma on nähtävillä tällä sivulla pian.
Symposium järjestetään yhteistyössä Helsingin yliopiston Lääkekehityksen tohtoriohjelman sekä Brain and Mindin tohtoriohjelmien kanssa, ja opiskelijat voivat saada osallistumisesta opintopisteitä (osallistuminen luennoille sekä power analyysi työpajaan 1 cr, osallistuminen posterilla + 1 cr).
Fincopa ja Ecopa tapahtuma - 6.10.2023.
Lokakuun 6. päivänä Fincopa (the Finnish National Consensus Platform for Alternatives) viettää 20-vuotisjuhlaansa! Tätä tilaisuutta varten Fincopa järjestää yhdessä Ecopan kanssa työpajan - Eläinkokeiden korvaaminen tieteessä ja viranomaisvaatimusten mukaisessa testauksessa. Tapahtuma järjestetään hybridinä, Teamsissa ja Helsingissä. Lisätietoja organisaatiosta löydät heidän verkkosivuiltaan, ja lisätietoja tapahtumasta täältä.
Virtuaalinen luentokoulutus tuottajille, eläinten hoitajille, eläinlääkäreille, opiskelijoille
27.1.2023 klo 11-16
Ilmainen, ilmoittaudu 10.1.2023 mennessä
FIN3R and OULAC joint webinar series 1 - 10/11/2022:
Animal-centric care and management – the importance of handling and training
Dr. Dorte Bratbo Sørensen, University of Copenhagen, Denmark
FIN3R and OULAC joint webinar series 2 - 17/11/2022:
Applied operant animal training in the lab – challenges and benefits
Dr. Dorte Bratbo Sørensen, University of Copenhagen, Denmark
FIN3R and OULAC joint webinar series 3 - 29/11/2022:
The influence of age on experimental outcomes and animal care
Dr. Paul Potter, Oxford Brookes University, UK
Kongressit ja symposiumit
Englanninkielinen Kolme R symposiumi 7.-8. joulukuuta, 2022: Improving the quality and translatability of biomedical research through 3R principles
The objective of this symposium is to give an overview and examples of the current state-of-the-art in fundamental biological and pharmacological research and drug development, with a focus on scientific excellence, research quality, communication and Three Rs in relation to using laboratory animals. The symposium is organized by the University of Helsinki Doctoral Programme in Drug Research and the Finnish 3R Center.
Join us to learn and discuss about recent developments in the field of Three Rs, good research practice and communication in animal research!
Also - workshop on power analysis and session on disease modelling!
Find out more and register at the link below:
- Swedish 3R Center, Swiss 3R Competence Center, Danish 3R Center, National Center for Replacement, Refinement & Reduction of Animals in Research (UK), and Charité 3R are hosting a series of webinars in June 2023. More information about the registration, materials, times and organizators is available here.
- A Transdisciplinary Conference on Alternative technologies and models (NAMs) to Reduce the use of laboratory animals in Industry, June 6-7th 2023 . Click here for registration and more information.
- The 2023 Animal Research Tomorrow (ART) Award Ceremony and Conference, June 8th 2023. Click here for registration and more information.
- Centro 3R is hosting a IV Annual Meeting in Milano, on September 13-15th, 2023. The topic of the meeting is "The role of 3Rs in the age of One Health: where we are and where we’re going", and more information about regisration, attendance and abstract submission (by July 1st, 2023) is available here.
- Swiss 3R Competence Center is hosting an annual confereces, Swiss 3R Day, with the focus on research advances, innovations, and issues in the field. The conference takes place in Lugano, on September 19th, 2023. More information and registration link is available here. Poster submission is open until August 19th, 2023. More information about submission could be found here.
- 12th World Congress on Alternatives and Animal Use in the Life Sciences (WC12), August 27-31st 2023. More information and registration is available here.
Education and Training Platform for Laboratory Animal Science, www.etplas.eu, https://etplas.eu/learn/
EU-10: Design of procedures and projects – level 1, https://etplas.eu/learn/eu-10-experimental-design/
EU-11: Design of procedures and projects – level 2, https://etplas.eu/learn/eu-11-1-design-of-procedures-and-projects/
EU-12: The severity assessment framework, https://etplas.eu/learn/eu-12-the-severity-assessment-framwork/
Eu-25: Project evaluation, https://etplas.eu/learn/eu-25-2-project-evaluation/
EU-52: Searching for (existing) non-animal alternatives, www.etplas.eu/learn/eu-52/
EU-60: Developing in vitro methods and approaches for scientific and regulatory use, www.etplas.eu/learn/eu-60/
Webinaarit ja seminaarit
- CPD LAS Webinars /Karolinska Institutet: “Proactive actions from industry to drive forward animal welfare, the 3Rs and science” will be presented by Dr. Kirsty Reid, Director Science Policy, European Federation of Pharmaceutical Industries and Associations (EFPIA), Brussels, Belgium.
Date: Tuesday, October 25, 2022 × Stockholm 1 PM CEST
The pharmaceutical industry is committed to the science-based phase-in of methods to replace the use of animals for scientific purposes and the deletion of animal tests which are obsolete or redundant. EFPIA members aim to lead progress on this by engaging in a wide range of practical activities to help drive the development, uptake and promotion of non-animal technologies (NATs) and new approach methodologies (NAMs) so that these can be phased-in as soon as it is scientifically possible to do so. There are a large number of initiatives underway within the pharma sector going beyond the legislative requirements for 3Rs. There are also a number of opportunities to join forces and drive this work forward on dialogue and collaborations. Dr Kirsty Reid will highlight some of these during the webinar session.
Dr. Kirsty Reid is team leader and Science Policy topic lead at EFPIA, where her focus includes innovation policy implementation with particular focus on science and research matters. She has over 16 years experience in EU public and regulatory affairs covering various EU legislation and policy areas, working specifically on animal experimentation; alternatives to animal testing, and environment, health and safety issues.
The Impact of the Animals’ Lived Experience” will be presented by Jennifer L Lofgren, Global Head of Animal Welfare and Compliance, Novartis Institutes for BioMedical Research, U.S.
Date: Thursday, 3 November 2022 × Stockholm 2 PM CET
While details such as how much nesting material we place in a cage, how we pick up a mouse during cage change, or which analgesic we administer may be fleeting and minor to in-vivo staff, these decisions can result in significant and impactful changes in the lived experience of our laboratory rodents. These impacts are not only to the animals’ welfare but also to the research results they produce. While these refinements were once considered nice to have, but far from necessary, published studies have now established that reducing stress associated with suboptimal housing, handling, and post-procedural pain management are important steps to improving laboratory rodent quality of life and the quality and success of the biomedical research to which they contribute. In this lecture we will explore this literature and learn about the relative impact on a variety of research models of both providing and withholding appropriate enrichment, reducing handling stress, and effective analgesics.
Jennie Lofgren, DVM, MS, DACLAM, is Global Head of Animal Welfare and Compliance at Novartis Institutes for BioMedical Research. At Novartis, Dr. Lofgren has worked with the global Animal Welfare Compliance team to increase education and transparency about the need for and value of animals in research and increased 3Rs opportunities for internal and external animal studies.
Webinar on Safer and Sustainable Innovation Approach for More Sustainable Nanomaterials and Nano-enabled Products will be held on Thursday 3 November 2022 at 14:30-16:30 CET / 09:30-11:30 EDT.
The Safer and Sustainable Innovation Approach (SSIA) is an approach aiming to boost safer and sustainable innovations by integrating safety and sustainability at an early stage of the design phase of innovative materials, products, applications, and processes. SSIA combines the Safe-and-Sustainable-by-Design (SSbD), Regulatory Preparedness (RP), and Trusted Environment (TE) concepts to identify and minimise sustainability impacts along with potential health and environmental risks in the innovation process. SSIA relies on early dialogue between industry and regulators and is facilitated by a Trusted Environment. SSIA aims to anticipate the regulatory challenges posed by innovative nanomaterials, nano-enabled products, or other advanced materials by minimising the gap between technological innovations and the development of suitable risk assessment tools and frameworks.
The second focus event of the Austrian 3R Center "Severe Suffering in Animal Experiments and How to Refine" will be held on the 7th of November 2022.
Annually, the Austrian 3R Center coordinates its focus topics with the Federal Ministry of Education, Science and Research and this time the focus is on severe suffering in animal experiments.
Webinar “Do ‘euthanasia’ methods for laboratory rodents really give them a ‘good death’?” will be presented by Dr Huw Golledge BSc PhD, Chief Executive & Scientific Director, Universities Federation for Animal Welfare, Hertfordshire, U.K.
Date: Friday, 25 November 2022 × Stockholm 1 PM CET
Euthanasia means a ‘good death’. Most laboratory rodents are killed with Carbon Dioxide (CO2), a procedure which is often referred to as euthanasia. In this talk I will summarise the extensive evidence that CO2 negatively impacts animal welfare when used to end the life of rats or mice. This evidence shows that CO2, even in low concentrations causes fear or anxiety which cannot be avoided if it used to kill rodents. Therefore, CO2 cannot be considered a method which offers a ‘good death’ for these species, and, moreover, that it should be considered a harm and factored into harm-benefit analyses when it is used to kill experimental subjects. I will then compare current and potential practical alternative methods to consider whether any of these offer the potential of a good death.
Huw Golledge is Chief Executive and Scientific Director of the Universities Federation for Animal Welfare (UFAW) - an international charity dedicated to the promotion of Science in the Service of Animal Welfare. Prior to joining UFAW he was an animal welfare researcher at Newcastle University in the UK and was a member of the UK’s national Animals in Science Committee from 2013-2016.
- Uniting in Toxicology: 18–22 September 2022 in Maastricht, The Netherlands.
- AALAS National Meeting, October 23–27, 2022, Louisville, Kentucky, USA.
- 21st International Congress of the European Society of Toxicology In Vitro (ESTIV), 21–25 November 2022 in Barcelona, Spain.