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With the lead of the Doctoral Program in Molecular Medicine at the University of Eastern Finland, FIN3R will host an “Alternative non-animal methods in biomedical research” course. The course is open to all graduate students who can earn credits for active participation. More information regarding the program and registration will be available shortly! 


Topic:Refining Rodent Oral Administration Protocols: Exploring Advantages, Limitations, and Recent Developments

By: Dr. Paulin Jirkof (University of Zurich).

Date: September 10, 2024, Helsinki 2 PM EEST


In drug development, a focus on oral formulations aligns with human treatment practices. Preclinical assessments demand crucial oral testing of compounds, often carried out through oral gavage in mice and rats. However, this widely used method lacks accuracy in replicating voluntary substance intake of humans, posing risks of injury and stress to laboratory rodents. This presentation scrutinizes the pros and cons of oral gavage and explores alternative approaches, including uncontrolled oral intake (e.g., via drinking water), and refined, controlled voluntary ingestion protocols. The Micropipette-Guided Drug Administration (MDA) method, employing palatable solutions like sweetened condensed milk diluted with water, will be introduced. The talk will evaluate evidence on the suitability of these alternative methods for administering various experimental substances, such as analgesics, tamoxifen or others, while prioritizing animal welfare.

SPEAKER: PD Dr. Paulin Jirkof, Office for Animal Welfare and 3R, University of Zurich, Switzerland

Paulin Jirkof earned her PhD in Neuroscience from the University of Zurich, Switzerland, and holds a Master of Advanced Studies in Management, Technology, and Economics from ETH Zurich, Switzerland. Her research focuses on refinement measures for laboratory rodents, with a particular emphasis on assessing and improving animal welfare. Currently serving as the 3R coordinator in the Office for Animal Welfare and 3R at the University of Zurich, Paulin also assumes the role of Chair on the executive board of the Swiss 3R Competence Center. Additionally, she is a board member of the Swiss Society for Laboratory Animal Science and serves as the Editor-in-Chief of the journal Laboratory Animals.

Register in advance for this meeting:

Registration for this webinar is required (**This webinar will be locked when the meeting room limit (300) is reached**). After registering, you will receive a confirmation email containing information about joining the meeting. During the webinar, please keep your cameras off and your microphones muted. After the main talk, we have time for discussion where you can participate with your face and voice!


FIN3R is hosting its Annual Symposium at the Kontinkangas Campus at the University of Oulu. Even will be organized online as well, and the topics of discussion will cover each of the 3Rs. More information about the agenda and registration will be available soon! 

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